Tore Curstedt - the basic science creator of porcine surfactant.
نویسندگان
چکیده
In 1980, two exceptional scientists met for the first time when they were both working at the Karolinska Institutet. Tore Curstedt and Bengt Robertson began their extraordinarily successful and long-lasting collaboration to develop a high-quality surfactant preparation, which could be produced in a reproducible way in large quantiTore Curstedt was born as an only child in 1946 in Piteå, a small town in the north of Sweden, about 800 km from Stockholm. He went to school in his hometown and in 1965 he moved to Stockholm for medical studies at the Karolinska Institutet. He started his research career in the Department of Medical and Physiological Chemistry at the Karolinska Institutet where, in 1974, he defended his doctoral thesis on Biosynthesis of Molecular Species of Phosphatidyl Cholines during Metabolism of [1,12 H 2 ] Ethanol. His main project was to develop methods in order to follow the deuterium transfer from deuterated ethanol to acyl residues and to different positions of the glycerol moieties of individual molecular species of each phospholipid class [1–3] . New methods for the isolation and separation of phospholipids were developed, and the turnover of the individual molecular species of different phospholipid classes in tissues, bile and plasma was determined. In 1975, Tore became Associate Professor and Senior Lecturer in Medical Chemistry at the Karolinska Institutet. Five years later, he decided to become a laboratory doctor and moved to the Department of Clinical Chemistry at the Karolinska University Hospital but with his research group still belonging to the Karolinska Institutet. In 2004, Tore Curstedt was appointed Assistant Director with responsibility for the Karolinska University Laboratory, which is the largest clinical laboratory in northern Europe. He retired from that position last year but is still active in research. Published online: October 5, 2014
منابع مشابه
Surfactant proteins B and C are both necessary for alveolar stability at end expiration in premature rabbits with respiratory distress syndrome.
Modified natural surfactant preparations, used for treatment of respiratory distress syndrome in premature infants, contain phospholipids and the hydrophobic surfactant protein (SP)-B and SP-C. Herein, the individual and combined effects of SP-B and SP-C were evaluated in premature rabbit fetuses treated with airway instillation of surfactant and ventilated without positive end-expiratory press...
متن کاملAcute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome.
In an attempt to restore functional surfactant to the lungs of patients with the adult respiratory distress syndrome (ARDS), we have treated six patients within the first 2 days of the onset of ARDS with a single dose of hydrophobic components of porcine surfactant. Surfactant (4 g in 50 ml) delivered via a bronchoscope in aliquots to each of the lobar bronchi was well tolerated and caused a mo...
متن کاملComparison of Polymyxin E and Polymyxin B as an Additive to Pulmonary Surfactant in Escherichia coli Pneumonia of Ventilated Neonatal Rabbits
Background: Ascending maternofetal bacterial infections often result in premature birth and neonatal respiratory distress. These neonates are treated with exogenous pulmonary surfactant (SF) and systemic antibiotics. Polymyxins are antimicrobiotic peptides that may bind to SF phospholipids. Objectives: Does topical administration of SF/polymyxin reduce bacterial growth in neonatal rabbit pneumo...
متن کاملImpact of the New Generation Reconstituted Surfactant CHF5633 on Human CD4+ Lymphocytes
BACKGROUND Natural surfactant preparations, commonly isolated from porcine or bovine lungs, are used to treat respiratory distress syndrome in preterm infants. Besides biophysical effectiveness, several studies have documented additional immunomodulatory properties. Within the near future, synthetic surfactant preparations may be a promising alternative. CHF5633 is a new generation reconstitute...
متن کاملBiophysical and physiological properties of a modified porcine surfactant enriched with surfactant protein A.
Surfactant protein A (SP-A), a major protein component of natural pulmonary surfactant, is absent in exogenous surfactants currently used in clinical practice. We investigated the physical and physiological properties of one of these modified natural surfactants (Curosurf) after enrichment with 5% SP-A (SP-A-Curosurf). A pulsating bubble system was used for in vitro assessments and ventilated n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Neonatology
دوره 106 3 شماره
صفحات -
تاریخ انتشار 2014